New study warns: Sucralose and Stevia may alter gut microbiome across generations
A study from the University of Chile suggests that sucralose and stevia may cause long-term biological changes to the gut microbiome, even in subsequent generations.
Opting for zero-calorie beverages as an alternative to traditional sugar has become a popular trend to manage weight and maintain stable blood glucose levels. However, a study recently published in the journal Frontiers in Nutrition has raised significant concerns regarding the long-term health implications of this practice.
A team of experts at the University of Chile discovered that two common sweeteners, sucralose and stevia, can alter the gut microbiome. This process not only diminishes beneficial compounds but also triggers changes in the activity of genes associated with metabolism and inflammatory responses.
To evaluate transgenerational impacts, a research team led by Dr. Francisca Concha Celume conducted an experiment on 47 mice. The groups were administered sucralose or stevia at doses equivalent to average human consumption. Notably, the subsequent offspring and grandchildren generations were not exposed to the sweeteners, receiving only plain water.
Analysis revealed that while the gut microbiome in the exposed mice showed higher diversity, the production of short-chain fatty acids from fiber fermentation decreased significantly. These compounds are essential for regulating gene expression and maintaining healthy metabolic function. This decline persisted into the grandchildren generation, despite those individuals never having consumed the sweeteners.
Dr. Francisca Concha Celume noted that these biological changes occurred even at doses currently deemed safe by regulatory bodies. While animal models cannot definitively confirm equivalent impacts on humans, the authors advise consumers to use these additives in moderation and emphasize the need for further in-depth research into their long-term biological effects.